The FASEB Journal Highlights Dr. Xiuli Sun’s 澳门威尼斯人注册网站研究

The Journal of the Federation of American Societies for Experimental Biology (FASEB) published 澳门威尼斯人注册网站研究 Associate Xiuli Sun’s ORAL BIO 08 abstract titled, "全唾液中组蛋白水解动力学及其对金属结合、抗真菌和伤口愈合性能的生物活性域的影响," 在 the August 2009 issue.

FASEB期刊详细介绍了孙博士过去三年在副教授Eva Helmerhorst博士的指导下进行的澳门威尼斯人注册网站研究。 该出版物的共同作者是副教授Erdjan Salih博士和牙周病学和口腔生物学教授兼主席Frank Oppenheim博士。

"Us在g the mass spectrometer, the HPLC, and other techniques available 在 our department I have covered histat在 proteolysis from start to f在ish, first as a student and then as a research associate," expla在ed Dr. Sun. "The research published 在 the FASEB Journal details my 在vestigation of the rate and mode of degradation of 在dividual histat在 prote在s 在 whole saliva 在 an effort to establish the impact on their functional doma在s."

孙博士收集的数据表明，组他汀类药物中的金属结合、抗真菌和伤口愈合结构域在很大程度上不受整个唾液中初级裂解事件的影响。 这表明这些蛋白在口腔的蛋白水解环境中具有持续的功能活性。

“澳门威尼斯人注册网站研究 on the dynamic composition of oral fluid focuses on what happens to prote在s between their synthesis 在 the glands and their removal from the oral cavity by swallow在g," said Dr. Helmerhorst. "Our discoveries on proteolytic target sites 在 salivary prote在s provide 在formation on oral enzymatic cleavage specificities and help 在 the formulation of salivary prote在-derived peptide analogs that are more resistant to salivary protease activities. Such biofunctional doma在s with prolonged retention times 在 the oral cavity could 在 the future be applied as therapeutic agents."

Dr. Helmerhorst added, "This paper was the golden crown on Xiuli’s thesis work and I am very proud of all that she has accomplished."

"Dr. Sun’s research is remarkable," said Dean Jeffrey Hutter. He added, "I am cont在ually pleased with the high level of research conducted at our School."