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Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue [Response to Letter]
An-Na Li,1,* Jing-Hua Sun,1,2,* Syafiqah Saidin,3,4 Jee Syuen Cheah,4,5 Chia-Hung Kuo,6 Ling Li,1 Jia-Shen Li,1 Ru-Yu Bai,1 Yong Diao,1 Hui-Min David Wang5,7–9
1School of Medicine, Huaqiao University, Quanzhou, Fujian, 362021, People’s Republic of China; 2Hebei Key Laboratory of Basic Medicine for Diabetes, Shijiazhuang Second Hospital, Shijiazhuang, Hebei, 050000, People’s Republic of China; 3IJN-UTM Cardiovascular Engineering Centre, Institute of Human Centered Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, 81310, Malaysia; 4Department of Biomedical Engineering & Health Sciences, Faculty of Electrical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Johor, 81310, Malaysia; 5Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China; 6Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, Republic of China; 7Regenerative Medicine and Cell Therapy Research Center; and Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China; 8Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan, Republic of China; 9Center of Applied Nanomedicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
*These authors contributed equally to this work
Correspondence: Hui-Min David Wang, Graduate Institute of Biomedical Engineering, National Chung Hsing University, No. 145, Xingda Road, South District, Taichung City, 402, Taiwan, Republic of China, Tel +886 4 22840733 #651 ; +886 935753718, Email [email protected] Yong Diao, School of Medicine, Huaqiao University, Quanzhou, Fujian, 362021, People’s Republic of China, Email [email protected]
View the original paper by Miss Li and colleagues
This is in response to the Letter to the Editor
Dear editor
Thank you for the letter. Firstly, the study tracked skin repair in mice for 30 days to study the long-term efficacy of the exosomes. Secondly, the safety of exosomes has been confirmed and reported in several published articles.1–3 Finally, we are researching the mechanisms by which exosomes improve skin status.
Disclosure
The authors report no conflicts of interest in this communication.
References
1. Figueroa-Valdés AI, Luz-Crawford P, Herrera-Luna Y, et al. Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis. J Nanobiotechnology. 2025;23. doi:10.1186/s12951-024-03088-x
2. Nazari H, Alborzi F, Heirani-Tabasi A, et al. Evaluating the safety and efficacy of mesenchymal stem cell-derived exosomes for treatment of refractory perianal fistula in IBD patients: clinical trial Phase I. Gastroenterol Rep. 2022;10:goac075. doi:10.1093/gastro/goac075
3. Chandran NS, Bhupendrabhai MN, Tan TT, et al. A Phase 1, open-label study to determine safety and tolerability of the topical application of mesenchymal stem/stromal cell (MSC) exosome ointment to treat psoriasis in healthy volunteers. Cytotherapy. 2025. doi:10.1016/j.jcyt.2025.01.007
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