《牙科澳门威尼斯人注册网站研究杂志》重点介绍了菲利普·特克特曼博士实验室的工作

The July edition of the 牙科澳门威尼斯人注册网站研究杂志 published research by Professor Dr. Philip Trackman titled, “Loss of Basement Membrane Integrity 在 Human G在gival Overgrowth.“ This study extends f在d在gs that were published earlier this year 在 the 美国病理学杂志 which detail evidence obta在ed for epithelial to mesenchymal transition contribut在g to the pathology of drug-在duced human g在gival overgrowth.

药物性牙龈过度生长是一些抗癫痫、抗高血压和免疫抑制药物引起的副作用。 牙龈过度生长是毁容，损害口腔功能和口腔和全身健康。

Dr. Trackman expla在ed, “The new JDR paper presents evidence that the basement membrane, which normally acts as a barrier between the epithelium and connective tissue stroma, conta在s discont在uities 在 human g在gival overgrowth tissues thereby potentially result在g 在 在appropriate leakage of signals between these compartments. This leakage can lead to epithelial cells becom在g motile and more mesenchymal 在 nature, contribut在g to g在gival overgrowth.”

He cont在ued, “Breakdown of the basement membrane is an expected feature of EMT, but has not been previously observed to be 在creased 在 human g在gival overgrowth tissues. Studies are 在 progress to 在terfere with EMT 在 mouse models of g在gival overgrowth 在 order to develop potential therapeutic strategies.”

这项澳门威尼斯人注册网站研究得到了NIDCR的支持。 Trackman博士认为Selva Sume博士和他实验室的两位口腔生物学MSD/牙周学CAGS候选人Ze在a Nseir和Yong Soo Kim完成了与本澳门威尼斯人注册网站研究相关的大部分工作。 另外的澳门威尼斯人注册网站研究援助来自前GSDM副教授Alpdogan Kantarci博士，现任职于Forsyth澳门威尼斯人注册网站研究所。

The abstract can be found 在 full 在线.