NeuroPhotonics Seminar – Sept 22, 2017
Ji Yi, Boston University Medical Center
Sept 22, 2017, 2:30-3:30pm, Kilachand Center 101
Probing the retinal vasculature and capillary function by multimodal optical imaging
Abstract: Human perceive over 80% of the information by vision. Retina, being responsible to convert the light into the electric signal, is thus the most metabolically demanding organ in our body. The high metabolic consumption relies on a well-organized, and dense circulation system to provide sufficient oxygen and nutrients. The disruption of the retinal vascular function can then lead to significant vision impairment and blindness, for example, in diabetic retinopathy and wet age-related macular degeneration. Since retina can be directly access by light, there is increasing thrust for advanced optical imaging techniques that can provide quantification of the retinal vascular function, even down to signal capillary level. In this talk, I will introduce our recent technical advancement on multi-model volumetric optical imaging that may quantify global oxygen metabolism, oxygenation within single capillary, disruption of blood-retinal barrier (BRB), and capillary dynamics. We will also discuss how these novel techniques can be translated into clinical applications, and impact our understanding of the vascular system in retina and in central nerve system.
To be followed by refreshments.