Big Data and AI in Immune-Mediated Conditions: Bridging Systems Biology and Clinical Practice

Immune-mediated conditions, spanning panvascular diseases and metabolic disease, are driven by dysregulated immune mechanisms that challenge diagnosis and therapeutic precision. The integration of artificial intelligence (AI) and big data analytics has emerged as a transformative force in immunology and system biology. These datasets—rich in longitudinal health records, multi-omics profiles, and sociodemographic variables—provide unparalleled opportunities to uncover disease patterns and predict outcomes. This Article Collections highlights how AI-driven analyses of real-world and population-level data—from global cohorts to clinical registries—are redefining research and care in immune-mediated conditions.