Atopic Dermatitis and Other Atopic Comorbidities

Atopic dermatitis (AD) is a chronic inflammatory cutaneous disorder. Currently, AD has been found to be associated with substantial patient burden and numerous atopic comorbidities, including asthma, allergic rhinitis, food allergy, and eosinophilic esophagitis, as well as nonatopic comorbidities, including allergic contact dermatitis, anxiety, depression, suicidality, infections, and cardiovascular disease. All these comorbidities led to the recognition of AD as a systemic disease. Of note, the relationship between AD and comorbidities is likely bidirectional and multifactorial, as well as some comorbidities may be secondary to the effects of the burden of chronic AD. This Article Collection explores the association between atopic dermatitis and other atopic comorbidities, shedding light on the shared pathophysiological mechanisms and the implications for clinical management.