Pragmatic and Observational Research

Tran TN, Chen S, Emmanuel B, Altraja A, Bourdin A, Sheu CC, Tsai MJ, Hoyte FC, Quinton A, Cook B, Bulathsinhala L, Henley W, Goh CYY, Liu Y, Ariti C, Carter V, Price DB

Pragmatic and Observational Research 2025, 16:51-66

Published Date: 18 March 2025

Original Research

A Prospective Observational Study to Evaluate the Actual Use of 1% Pimecrolimus in Chinese Patients with Mild-to-Moderate Atopic Dermatitis Affecting Sensitive Skin Areas

Xie Z, Chang J, Ma L, Shen C, Zhang L, An Q, Wang H, Dou X, Zheng Y, Ye C, Gao Y

Pragmatic and Observational Research 2025, 16:39-49

Published Date: 7 March 2025

Original Research

Treatment Patterns, Adverse Events, and Clinical Outcomes with Steroidal Mineralocorticoid Receptor Antagonists: A Retrospective Analysis of Administrative Claims Data (RELICS)

Richard EL, Desai NR, Willey VJ, Gay A, Scott C, Folkerts K, Pessina E, Singh R, Teng CC, Oberprieler NG

Pragmatic and Observational Research 2025, 16:27-37

Published Date: 26 February 2025

Original Research

Validation of Mortality Data Sources Compared to the National Death Index in the Healthcare Integrated Research Database

Jamal-Allial A, Sponholtz T, Vojjala SK, Paullin M, Papazian A, Eshete B, Mahmoudpour SH, Verpillat P, Beachler DC

Pragmatic and Observational Research 2025, 16:19-25

Published Date: 7 February 2025

Review

Review of Challenges in Performing Real-World Evidence Studies for Nonprescription Products

Maihöfner C, Mallick-Searle T, Vollert J, Kalita P, Sood Sethi V

Pragmatic and Observational Research 2025, 16:7-18

Published Date: 23 January 2025

Research Letter

Measuring Diagnostic Quality: The Capacity of Routinely Collected Data and Applications to Chronic Respiratory Disease

Mountain R, Gatheral T, Haslam P, Heys K, Knight J

Pragmatic and Observational Research 2025, 16:1-6

Published Date: 16 January 2025

Original Research

Detection of Patient-Level Immunotherapy-Related Adverse Events (irAEs) from Clinical Narratives of Electronic Health Records: A High-Sensitivity Artificial Intelligence Model

Zitu MM, Gatti-Mays ME, Johnson KC, Zhang S, Shendre A, Elsaid MI, Li L

Pragmatic and Observational Research 2024, 15:243-252

Published Date: 20 December 2024

Original Research

Validation and Final Results from the First Cardiac Lead Post-Approval Study Using Real-World Data

Mullane S, Hicks JB, Sharmin K, Harrell C, Rock A, Miller C

Pragmatic and Observational Research 2024, 15:233-241

Published Date: 19 December 2024

Original Research

Preserved Ratio Impaired Spirometry in US Primary Care Patients Diagnosed with Chronic Obstructive Pulmonary Disease

Evans A, Tarabichi Y, Pace WD, Make B, Bushell N, Carter V, Chang KL, Fox C, Han MK, Kaplan A, Kocks JWH, Le Lievre C, Roussos A, Skolnik N, Soriano JB, Yawn BP, Price D

Pragmatic and Observational Research 2024, 15:221-232

Published Date: 13 December 2024

Original Research

Patient Characteristics, Management, and Outcomes of Adult Asthma in a Singapore Population: Data from the SDG-CARE Asthma Registry

Koh MS, Lam SSW, Xu X, Wu JT, Ratnasingham P, Marsel R, Ong MEH, Matchar DB, Tan NC, Loo CM

Pragmatic and Observational Research 2024, 15:209-220

Published Date: 7 December 2024

Editorial

Improving the Transparency and Replicability of Consensus Methods: Respiratory Medicine as a Case Example

Rolfe MJ, Winchester CC, Chisholm A, Price DB

Pragmatic and Observational Research 2024, 15:201-207

Published Date: 15 October 2024

Original Research

Non-Alcoholic Steatohepatitis Patient Characterization and Real-World Management Approaches in Italy

Bugianesi E, Miele L, Donnarumma G, Grau K, Mancuso M, Prasad P, Leith A, Higgins V

Pragmatic and Observational Research 2024, 15:185-200

Published Date: 10 October 2024

Method

Comparing Machine Learning and Advanced Methods with Traditional Methods to Generate Weights in Inverse Probability of Treatment Weighting: The INFORM Study

Kwak D, Liang Y, Shi X, Tan X

Pragmatic and Observational Research 2024, 15:173-183

Published Date: 4 October 2024

Original Research

Involvement of Root Canal Treatment in Pro-Inflammatory Processes – A Real-World Study

Diederich J, Müller KE

Pragmatic and Observational Research 2024, 15:165-172

Published Date: 24 September 2024

Review

UK Electronic Healthcare Records for Research: A Scientometric Analysis of Respiratory, Cardiovascular, and COVID-19 Publications

Massen GM, Blamires O, Grainger M, Matta M, Twumasi RMG, Joshi T, Laity A, Nakariakova E, Thavaranjan T, Sheikh A, Quint JK

Pragmatic and Observational Research 2024, 15:151-164

Published Date: 15 August 2024

Review

Therapeutic Advances in Obesity: How Real-World Evidence Impacts Affordability Beyond Standard of Care

Patoulias D, Koufakis T, Ruža I, El-Tanani M, Rizzo M

Pragmatic and Observational Research 2024, 15:139-149

Published Date: 6 August 2024

Original Research

A Real-World Study on the Short-Term Efficacy of Amlodipine in Treating Hypertension Among Inpatients

Wang T, Tan J, Wang T, Xiang S, Zhang Y, Jian C, Jian J, Zhao W

Pragmatic and Observational Research 2024, 15:121-137

Published Date: 6 August 2024

Original Research

Quality of Life in Patients Affected by Facial Basal Cell Carcinoma: Prospective Longitudinal Pilot Study and Validation of Skin Cancer Index in Lithuanian Language

Stundys D, Kučinskaitė A, Gervickaitė S, Tarutytė G, Grigaitienė J, Tutkuviene J, Jančorienė L

Pragmatic and Observational Research 2024, 15:103-119

Published Date: 5 August 2024

Original Research

Advanced Multi-Layer Watertight Closure versus Conventional Closure in Total Hip and Knee Replacement Surgery

Flener JL, Chen BPH, Ernst FR, Libolt A, Gunja NJ, Barrett WP

Pragmatic and Observational Research 2024, 15:93-102

Published Date: 19 July 2024

Response to Letter

Critique on “Real-World Effectiveness of First-Line Lenvatinib Therapy in Advanced Hepatocellular Carcinoma: Current Insights” [Response to Letter]

Biachi de Castria T, Kim RD

Pragmatic and Observational Research 2024, 15:91-92

Published Date: 10 July 2024

Letter

Critique on “Real-World Effectiveness of First-Line Lenvatinib Therapy in Advanced Hepatocellular Carcinoma: Current Insights” [Letter]

Goyal MK, Khubber M, Mehta V

Pragmatic and Observational Research 2024, 15:89-90

Published Date: 1 July 2024

Review

Real-World Effectiveness of First Line Lenvatinib Therapy in Advanced Hepatocellular Carcinoma: Current Insights

Biachi de Castria T, Kim RD

Pragmatic and Observational Research 2024, 15:79-87

Published Date: 10 June 2024

Original Research

Using Claims Data to Predict Pre-Operative BMI Among Bariatric Surgery Patients: Development of the BMI Before Bariatric Surgery Scoring System (B3S3)

Wong J, Li X, Arterburn DE, Li D, Messenger-Jones E, Wang R, Toh S

Pragmatic and Observational Research 2024, 15:65-78

Published Date: 27 March 2024

Original Research

Trends in Systemic Glucocorticoid Utilization in the United Kingdom from 1990 to 2019: A Population-Based, Serial Cross-Sectional Analysis

Menzies-Gow AN, Tran TN, Stanley B, Carter VA, Smolen JS, Bourdin A, Fitzgerald JM, Raine T, Chapaneri J, Emmanuel B, Jackson DJ, Price DB

Pragmatic and Observational Research 2024, 15:53-64

Published Date: 15 March 2024

Review

Difficult-To-Treat and Severe Asthma: Can Real-World Studies On Effectiveness of Biological Treatments Change the Lives of Patients?

Pelaia C, Giacalone A, Ippolito G, Pastore D, Maglio A, Piazzetta GL, Lobello N, Lombardo N, Vatrella A, Pelaia G

Pragmatic and Observational Research 2024, 15:45-51

Published Date: 11 March 2024

Original Research

Obesity Paradox in Heart Failure with Mildly Reduced Ejection Fraction

Reinhardt M, Schupp T, Abumayyaleh M, Lau F, Schmitt A, Abel N, Akin M, Rusnak J, Akin I, Behnes M

Pragmatic and Observational Research 2024, 15:31-43

Published Date: 5 March 2024

Original Research

Drug Repurposing in Crohn’s Disease Using Danish Real-World Data

Shakibfar S, Allin KH, Jess T, Barbieri MA, Battini V, Simoncic E, Kirchgesner J, Ulven T, Sessa M

Pragmatic and Observational Research 2024, 15:17-29

Published Date: 21 February 2024

Original Research

Risk of Pneumonia in Patients with COPD Initiating Fixed Dose Inhaled Corticosteroid (ICS) / Long-Acting Bronchodilator (LABD) Formulations Containing Extrafine Beclometasone Dipropionate versus Patients Initiating LABD Without ICS

Price D, Henley W, Cançado JED, Fabbri LM, Kerstjens HA, Papi A, Roche N, Şen E, Singh D, Vogelmeier CF, Nudo E, Carter V, Skinner D, Vella R, Soriano JB, Kots M, Georges G

Pragmatic and Observational Research 2024, 15:1-16

Published Date: 20 January 2024

Original Research

Prediction Model with Validation for Polioseronegativity in Malnourished Children from Poliomyelitis Transmission High-Risk Area of the Democratic Republic of the Congo (DRC)

Mwamba GN, Kabamba M, Hoff NA, Mukadi PK, Musene KK, Gerber SK, Halbrook M, Sinai C, Fuller T, Voorman A, Mawaw PM, Numbi OL, Wemakoy EO, Mechael PN, Tamfum JJM, Mapatano MA, Rimoin AW, Lusamba Dikassa PS

Pragmatic and Observational Research 2023, 14:155-165

Published Date: 21 December 2023

Review

Avelumab for Advanced Merkel Cell Carcinoma: Global Real-World Data on Patient Response and Survival

Lohray R, Verma KK, Wang LL, Haynes D, Lewis DJ

Pragmatic and Observational Research 2023, 14:149-154

Published Date: 16 November 2023

Original Research

Adult Severe Asthma Registries: A Global and Growing Inventory

Cushen B, Koh MS, Tran TN, Martin N, Murray R, Uthaman T, Goh CYY, Vella R, Eleangovan N, Bulathsinhala L, Maspero JF, Peters MJ, Schleich F, Pitrez P, Christoff G, Sadatsafavi M, Torres-Duque CA, Porsbjerg C, Altraja A, Lehtimäki L, Bourdin A, Taube C, Papadopoulos NG, Zsuzsanna C, Björnsdóttir U, Salvi S, Heffler E, Iwanaga T, al-Ahmad M, Larenas-Linnemann D, van Boven JF, Aarli BB, Kuna P, Loureiro CC, Al-lehebi R, Lee JH, Marina N, Bjermer L, Sheu CC, Mahboub B, Busby J, Menzies-Gow A, Wang E, Price DB

Pragmatic and Observational Research 2023, 14:127-147

Published Date: 20 October 2023

Original Research

Development of an Asthma Exacerbation Risk Prediction Model for Conversational Use by Adults in England

Kallis C, Calvo RA, Schuller B, Quint JK

Pragmatic and Observational Research 2023, 14:111-125

Published Date: 4 October 2023

Review

Tactical Considerations for Designing Real-World Studies: Fit-for-Purpose Designs That Bridge Research and Practice

Dreyer NA, Mack CD

Pragmatic and Observational Research 2023, 14:101-110

Published Date: 25 September 2023

Review

Real World Data Studies of Antineoplastic Drugs: How Can They Be Improved to Steer Everyday Use in the Clinic?

George G, Russell B, Rigg A, Coolen ACC, Van Hemelrijck M

Pragmatic and Observational Research 2023, 14:95-100

Published Date: 6 September 2023

Review

Real-World Impact of Robotic-Assisted Bronchoscopy on the Staging and Diagnosis of Lung Cancer: The Shape of Current and Potential Opportunities

Ortiz-Jaimes G, Reisenauer J

Pragmatic and Observational Research 2023, 14:75-94

Published Date: 5 September 2023

Review

Real-World Use of Immunotherapy for Hepatocellular Carcinoma

Sara A, Ruff SM, Noonan AM, Pawlik TM

Pragmatic and Observational Research 2023, 14:63-74

Published Date: 21 August 2023

Review

Clinical Management of COPD in the Real World: Can Studies Reveal Errors in Management and Pathways to Improve Patient Care?

Halpin DM

Pragmatic and Observational Research 2023, 14:51-61

Published Date: 1 August 2023

Original Research

Data-Resource Profile: United Kingdom Optimum Patient Care Research Database

Lynam A, Curtis C, Stanley B, Heatley H, Worthington C, Roberts EJ, Price C, Carter V, Dennis J, McGovern A, Price D

Pragmatic and Observational Research 2023, 14:39-49

Published Date: 27 April 2023

Original Research

Administrative Databases and Diagnostic Therapeutic and Assistance Paths -PDTA- in the Monitoring Treatment of Rheumatoid Arthritis: The Experience of ATS Pavia

Bruno GM, Valentino MC, Brunetti A, Di Matteo S, Begovic I, Croce E, Sakellariou G, Bugatti S, Perotti P, Vecchio S, Migliazza S, Langella R, Colombo GL

Pragmatic and Observational Research 2023, 14:29-38

Published Date: 19 April 2023

Original Research

Alignment of Physician-Stated vs Clinically Derived Reference Fibrosis Score in Patients with Non-Alcoholic Steatohepatitis: A Real-World European Survey

Anstee QM, Hallsworth K, Lynch N, Hauvespre A, Mansour E, Kozma S, Bottomley J, Milligan G, Piercy J, Higgins V

Pragmatic and Observational Research 2023, 14:13-27

Published Date: 24 February 2023

Original Research

Real-Life Effectiveness of MP-AzeFlu (Dymista®) in Swedish Patients with Persistent Allergic Rhinitis, Assessed by the Visual Analogue Scale

Stjärne P, Nguyen DT, Kuhl HC

Pragmatic and Observational Research 2023, 14:1-11

Published Date: 4 January 2023

Original Research

Impact of the COVID-19 Pandemic on Trauma Service Utilization at a New York City Level I Trauma Center

Rosen B, Pelle AL, Lakhi NA

Pragmatic and Observational Research 2022, 13:93-103

Published Date: 5 September 2022

Short Report

Detection of Short-Term Side Effects of ChAdOx1 nCoV-19 Vaccine: A Cross-Sectional Study in a War-Torn Country

Alshakka M, Hatem NAH, Badullah W, Alsakaf R, Rageh A, Yousef SA, Mohamed Ibrahim MI

Pragmatic and Observational Research 2022, 13:85-91

Published Date: 25 August 2022

Original Research

A Phase IV Study on Safety, Tolerability and Efficacy of Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate in Treatment Naïve Adult Indian Patients Living with HIV-1

Dravid A, Morkar D, Prasad D, Ramapuram JT, Patel KV, Naik KS, Bhrusundi M, Kulkarni M, Hegde S, Anuradha S, Nageswaramma S, Madan S, Jayaprakash T, Kulkarni V

Pragmatic and Observational Research 2022, 13:75-84

Published Date: 10 August 2022