Journal of Hepatocellular Carcinoma | Volume 12

Munker S, Rodriguez I, Bernhart K, Ben Khaled N, Findik M, Siegmund LK, Ye L, Reiter FP, Roessler D, Nasseh D, Balcar L, Pomej K, Scheiner B, Weiss C, Pinter M, Seidensticker M, Mayerle J, Philipp AB, De Toni EN

Journal of Hepatocellular Carcinoma 2025, 12:855-864

Published Date: 5 May 2025

Review

The Synergistic Mechanisms and Prospects of Transarterial Chemoembolization Combined with Immunotherapy for Hepatocellular Carcinoma

Chen QF, Chen S, Zhao M

Journal of Hepatocellular Carcinoma 2025, 12:841-854

Published Date: 30 April 2025

Perspectives

Hepatic Arterial Infusion Chemotherapy for Hepatocellular Carcinoma: A Three-Dimensional Visualization Perspective

Tan Y, Li PP, Liu H, Zhu JY, Wu QS

Journal of Hepatocellular Carcinoma 2025, 12:837-840

Published Date: 28 April 2025

Original Research

The Impact of Microwave Ablation on Recurrence and Metastasis of Hepatocellular Carcinoma: Insights From Animal Studies and Cytokine Profiling

Wang Y, Tan H, Wen C, Chen S, Zheng G, Qi H, Xie L, Shen L, Cao F, Fan W

Journal of Hepatocellular Carcinoma 2025, 12:825-835

Published Date: 26 April 2025

Original Research

A Novel Prognostic Signature Integrating Immune and Glycolytic Pathways for Enhanced Prognosis and Immunotherapy Prediction in Hepatocellular Carcinoma

Zhang Z, Zhao H, Wang P, Geng X, Yin M, Liu Y, Zhang S, Liang Y, Ji J, Zheng G

Journal of Hepatocellular Carcinoma 2025, 12:805-823

Published Date: 18 April 2025

Original Research

Atezolizumab Plus Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Real-World Experience From a US Community Oncology Network

Cosgrove D, Tan R, Osterland AJ, Hernandez S, Ogale S, Mahrus S, Murphy J, Wilson T, Patton G, Loaiza-Bonilla A, Singal AG

Journal of Hepatocellular Carcinoma 2025, 12:791-804

Published Date: 18 April 2025

Review

Optimizing Treatment Selection for Early Hepatocellular Carcinoma Based on Tumor Biology, Liver Function, and Patient Status

Li X, Xu Y, Ou Y, Li H, Xu W

Journal of Hepatocellular Carcinoma 2025, 12:777-790

Published Date: 16 April 2025

Original Research

A Novel Nomogram Model for Predicting the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection

Wu Y, Wang M, Zhang Z, Chen G, Zhang B

Journal of Hepatocellular Carcinoma 2025, 12:765-775

Published Date: 16 April 2025

Original Research

Prognostic Analysis of Elderly Patients with Hepatocellular Carcinoma: an Exploration and Machine Learning Model Prediction Based on Age Stratification and Surgical Approach

Cai C, Zhu H, Li B, Tang C, Ren Y, Guo Y, Li J, Wang L, Li D, Li D

Journal of Hepatocellular Carcinoma 2025, 12:747-764

Published Date: 14 April 2025

Original Research

Serum Osteopontin Enhances Hepatocellular Carcinoma Diagnosis and Predicts Anti-PD-L1 Immunotherapy Benefit

Wu M, Zou F, He S, Pi Y, Song Y, Chen S, Li L

Journal of Hepatocellular Carcinoma 2025, 12:729-745

Published Date: 13 April 2025

Original Research

Preoperative Prediction of Macrotrabecular-Massive Hepatocellular Carcinoma Using Machine Learning-Based Ultrasomics

Li Y, Duan S, Ren S, Li D, Ma Y, Bu D, Liu Y, Li X, Cai X, Zhang L

Journal of Hepatocellular Carcinoma 2025, 12:715-727

Published Date: 12 April 2025

Case report

Rare Gingival Metastasis Occurring After Conversion Therapy Followed by Resection of Initially Unresectable Hepatocellular Carcinoma: A Case Report

Zhan J, Huang H, Zhan T, Liu X, Cheng Q

Journal of Hepatocellular Carcinoma 2025, 12:705-713

Published Date: 9 April 2025

Original Research

Identification of FDFT1 and PGRMC1 as New Biomarkers in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocellular Carcinoma by Deep Learning

Liu Q, Yang Y, Wang Y, Wei S, Yang L, Liu T, Yu Z, Feng Y, Yao P, Zhu Q

Journal of Hepatocellular Carcinoma 2025, 12:685-704

Published Date: 5 April 2025

Original Research

ALBI Grade Enables Risk Stratification for Bleeding Events and Refines Prognostic Prediction in Advanced HCC Following Atezolizumab and Bevacizumab

Stefanini B, Fulgenzi CAM, Scheiner B, Korolewicz J, Cheon J, Nishida N, Ang C, Marron TU, Wu YL, Saeed A, Wietharn B, Rimassa L, Pirozzi A, Cammarota A, Pressiani T, Pinter M, Balcar L, Huang YH, Mehan A, Phen S, Vivaldi C, Salani F, Masi G, Bettinger D, Vogel A, Schönlein M, von Felden J, Schulze K, Wege H, Samson A, Galle PR, Kudo M, Manfredi GF, Celsa C, Awosika N, Cortellini A, Singal AG, Sharma R, Chon HJ, Tovoli F, Piscaglia F, Pinato DJ, D’Alessio A

Journal of Hepatocellular Carcinoma 2025, 12:671-683

Published Date: 4 April 2025

Original Research

Machine Learning-Based Model Used for Predicting the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B

Wu T, Yan J, Xiong F, Liu X, Zhou Y, Ji X, Meng P, Jiang Y, Hou Y

Journal of Hepatocellular Carcinoma 2025, 12:659-670

Published Date: 3 April 2025

Editorial

Access to Medical Research is a Basic Human Right: A Roadmap to Research Integration Into a Practical Hepatocellular Carcinoma Treatment Allocation Algorithm (HCC-TAA)

Kaseb AO

Journal of Hepatocellular Carcinoma 2025, 12:649-657

Published Date: 28 March 2025

Original Research

The Expression of Ferroptosis-Related Genes in Hepatocellular Carcinoma and Their Relationships With Prognosis

Li H, Hu X, Wang L, Gu X, Chen S, Tang Y, Chen Y, Chen J, Yuan Z, Wang Y

Journal of Hepatocellular Carcinoma 2025, 12:629-648

Published Date: 20 March 2025

Original Research

Prediction Model of Survival in Unresectable HCC with Central Bile Duct Invasion Receiving TACE After Biliary Drainage: TEMP Score

Fan W, Zheng X, Zhang W, Zhu B, Wu Y, Xue M, Tang R, Huang Z, Qiao L, Lu M, Wu J, Tang Y, Chen J, Huang S, Bai M, Li J

Journal of Hepatocellular Carcinoma 2025, 12:615-628

Published Date: 20 March 2025

Original Research

Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells

Zhang J, Tian T, Tian S, Yao J, Zhang Y, Xie R, Yang T, Han B

Journal of Hepatocellular Carcinoma 2025, 12:597-614

Published Date: 19 March 2025

Original Research

A Chemotherapy Response-Related Gene Signature and DNAJC8 as Key Mediators of Hepatocellular Carcinoma Progression and Drug Resistance

Ye Y, Zeng Y, Huang S, Zhu C, Wang Q

Journal of Hepatocellular Carcinoma 2025, 12:579-595

Published Date: 20 March 2025

Original Research

Combined TACE with Targeted and Immunotherapy versus TACE Alone Improves DFS in HCC with MVI: A Multicenter Propensity Score Matching Study

Chen X, Wu X, Peng W, Liu L, Liu X, Wan X, Xu H, Zheng Y, Zhao H, Mao Y, Lu X, Sang X, Chang X, Zhou K, Pan J, Guan M, Hu D, Tan H, Zhang Y, Du S

Journal of Hepatocellular Carcinoma 2025, 12:561-577

Published Date: 19 March 2025

Rapid Communication

Radiation Segmentectomy or Ablative External Beam Radiation Therapy as Initial Treatment for Solitary Hepatocellular Carcinoma: A Multicenter Experience

De la Garza-Ramos C, Montazeri SA, LeGout JD, Lewis AR, Frey GT, Paz-Fumagalli R, Hallemeier CL, Rutenberg MS, Ashman JB, Toskich BB

Journal of Hepatocellular Carcinoma 2025, 12:553-559

Published Date: 13 March 2025

Original Research

Lasso-Based Nomogram for Predicting Early Recurrence Following Radical Resection in Hepatocellular Carcinoma

Zheng G, Zheng M, Hu P, Zhu Y, Zhang W, Zhang F

Journal of Hepatocellular Carcinoma 2025, 12:539-552

Published Date: 12 March 2025

Original Research

Efficacy and Safety of Ipilimumab Plus Anti-PD-1/PD-L1 Antibodies Combination Therapy in Advanced Hepatocellular Carcinoma Patients Progressing After Multiple Lines of Treatment: A Retrospective Multicenter Study

Zheng SS, Wu JF, Zhang ZZ, Wu YF, Chen YJ, Qian S, Zhang BH

Journal of Hepatocellular Carcinoma 2025, 12:527-537

Published Date: 11 March 2025

Original Research

The Diagnostic Performance of AFP, AFP-L3, DCP, CA199, and Their Combination for Primary Liver Cancer

Liu Y, Jiang W, Li X, Zhao H, Wang S

Journal of Hepatocellular Carcinoma 2025, 12:513-526

Published Date: 6 March 2025

Review

Improving Health-Related Quality of Life in Hepatocellular Carcinoma Patients: Key Methodologies for Assessing Patient Reported Outcomes and Intervention Targets

Moon AM, Kappelman MD, Barritt IV AS, Evon DM, Sanoff HK, Wagner LI

Journal of Hepatocellular Carcinoma 2025, 12:497-511

Published Date: 5 March 2025

Original Research

Prognostic Value of Changes in Combined Child–Pugh Class and ALBI Grade in Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Plus Targeted Therapy and PD-(L)1 Inhibitors

Huang X, Cao X, Kong Y, Tang F, Cong T, Zhou X

Journal of Hepatocellular Carcinoma 2025, 12:481-496

Published Date: 4 March 2025

Review

Research Progress of Liver Cancer Recurrence Based on Energy Metabolism of Liver Cancer Stem Cells

Wu M, Wang H, Wu X, Zeng H, Miao M, Song Y

Journal of Hepatocellular Carcinoma 2025, 12:467-480

Published Date: 3 March 2025

Case report

A Case of DEB-TACE Combined with Anlotinib for Treatment of Liver Metastasis from Retroperitoneal Leiomyosarcoma

Cui H, Xu Q, Han Z, Zhang S

Journal of Hepatocellular Carcinoma 2025, 12:459-465

Published Date: 2 March 2025

Original Research

Efficacy and Safety of Transarterial Chemoembolization Combined with Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib for Intermediate-Stage Hepatocellular Carcinoma Beyond Up-To-Seven: A Multicentre, Retrospective Propensity Score Matching Analysis

Zhong S, Zhang F, Zhang H, Hu H, Zeng Q, Li Y, Wei Q

Journal of Hepatocellular Carcinoma 2025, 12:445-458

Published Date: 1 March 2025

Original Research

Integrative Analysis of scRNA-Seq and Bulk RNA-Seq Identifies Plasma Cell Related Genes and Constructs a Prognostic Model for Hepatocellular Carcinoma

Tang M, Xu Y, Pan M

Journal of Hepatocellular Carcinoma 2025, 12:427-444

Published Date: 26 February 2025

Original Research

Increment of Skeletal Muscle Mass Predicts Survival Benefit for Hepatocellular Carcinoma Treated with Transarterial Chemoembolization Combining Molecular Targeted Agents and Immune Checkpoint Inhibitors

Chen W, Yan HT, Zhang JX, Shen X, Liu J, Liu S, Shi HB, Ding Y, Zu QQ

Journal of Hepatocellular Carcinoma 2025, 12:415-426

Published Date: 27 February 2025

Review

Systemic Treatment for Unresectable Hepatocellular Carcinoma: A Surgeon’s Perspective

Zhu XD, Zhao L, Li B, Cheng Y, Sun HC

Journal of Hepatocellular Carcinoma 2025, 12:399-413

Published Date: 26 February 2025

Original Research

Application of Intravoxel Incoherent Motion in the Prediction of Intra-Tumoral Tertiary Lymphoid Structures in Hepatocellular Carcinoma

Ma L, Liao S, Zhang X, Zhou F, Geng Z, Hu J, Zhang Y, Zhang C, Meng T, Wang S, Xie C

Journal of Hepatocellular Carcinoma 2025, 12:383-398

Published Date: 22 February 2025

Original Research

Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis

Lu L, Zhou X, Zheng J, Li D

Journal of Hepatocellular Carcinoma 2025, 12:367-382

Published Date: 21 February 2025

Original Research

Machine Learning Prognostic Model for Post-Radical Resection Hepatocellular Carcinoma in Hepatitis B Patients

Zhu D, Tulahong A, Abuduhelili A, Liu C, Aierken A, Lin Y, Jiang T, Lin R, Shao Y, Aji T

Journal of Hepatocellular Carcinoma 2025, 12:353-365

Published Date: 19 February 2025

Original Research

Outcomes and Prognostic Factors in Cirrhotic Patients with Acute Variceal Bleeding and Hepatocellular Carcinoma: A Nested Case–Control Study

Liu G, Xiao S, Xiang T, Wang X, Shen Y, Yang L, Luo X

Journal of Hepatocellular Carcinoma 2025, 12:343-352

Published Date: 19 February 2025

Original Research

Comprehensive Analysis of the Role of Heat Shock Proteins in the Immune Microenvironment and Clinical Significance of Hepatocellular Carcinoma

Xiao H, Wang B, Xiong S, Li C, Ding Y, Chao D, Mei B, Shen N, Luo G

Journal of Hepatocellular Carcinoma 2025, 12:325-342

Published Date: 17 February 2025

Original Research

Apolipoprotein E: A Potential Prognostic and Diagnostic Biomarker for Hepatocellular Carcinoma

Li Y, Lu R, Abuduhailili X, Feng Y

Journal of Hepatocellular Carcinoma 2025, 12:301-324

Published Date: 17 February 2025

Original Research

Risk Factors and Predictive Analysis of Acute Severe Abdominal Pain After Hepatic Artery Infusion Chemotherapy in Patients with Hepatocellular Carcinoma

Li J, Shi C, Chen J, Zhao Y, Du J, Song J

Journal of Hepatocellular Carcinoma 2025, 12:289-299

Published Date: 17 February 2025

Original Research

MRI Features and Neutrophil-to-Lymphocyte Ratio (NLR)-Based Nomogram to Predict Prognosis of Microvascular Invasion-Negative Hepatocellular Carcinoma

Wei Y, Huang X, Pei W, Zhao Y, Liao H

Journal of Hepatocellular Carcinoma 2025, 12:275-287

Published Date: 15 February 2025

Original Research

Effect of Narrow-Margin Hepatectomy Combined with Intraoperative Radiotherapy on Long-Term Prognosis of Patients with Centrally Located Hepatocellular Carcinoma: A Propensity Score Matching Analysis

Tao C, Liu L, Hu N, Wang H, Zhang K, Liu Y, Wu F, Wang L, Rong W, Wu J

Journal of Hepatocellular Carcinoma 2025, 12:261-274

Published Date: 15 February 2025

Original Research

Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study

Guan R, Zheng Z, Deng M, Mei J, Lin Y

Journal of Hepatocellular Carcinoma 2025, 12:247-260

Published Date: 10 February 2025

Original Research

Tolerability and Effectiveness of Regorafenib Treatment in Patients with Unresectable Hepatocellular Carcinoma: Real-World Data from the United States

Finn RS, Iyer R, Kalman RS, Parikh ND, Cabrera R, Babajanyan S, Kaseb AO

Journal of Hepatocellular Carcinoma 2025, 12:231-246

Published Date: 7 February 2025

Original Research

Simultaneous Liver Venous Deprivation Following Hepatic Arterial Chemoembolization Before Major Hepatectomy for Hepatocellular Carcinoma: A New Methods to Achieve Hypertrophy Liver Remnant

Zhang S, Song R, Hou C, Yao H, Xu J, Zhou H, Li S, Cai W, Fei Y, Meng F, Yin D, Wang J, Zhang S, Liu Y, Wang J, Liu L

Journal of Hepatocellular Carcinoma 2025, 12:219-229

Published Date: 5 February 2025

Original Research

Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma ≤3 cm in Potentially Transplantable Patients: A Over 10-Year Survival Study

Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

Journal of Hepatocellular Carcinoma 2025, 12:205-218

Published Date: 3 February 2025

Original Research

TRACE Model: Predicting Treatment Response to Transarterial Chemoembolization in Unresectable Hepatocellular Carcinoma

Wang W, Zhang Q, Cui Y, Zhang S, Li B, Xia T, Song Y, Zhou S, Ye F, Xiao W, Cao K, Chi Y, Qu J, Zhou G, Chen Z, Zhang T, Chen X, Ju S, Wang YC

Journal of Hepatocellular Carcinoma 2025, 12:193-203

Published Date: 29 January 2025

Original Research

The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection

Yu ZC, Fang ZK, Yu Y, Liu SY, Wang KD, Shi ZJ, Jin LM, Huang XK, Lu Y, Shen GL, Liu JW, Huang DS, Zhang CW, Liang L

Journal of Hepatocellular Carcinoma 2025, 12:183-192

Published Date: 30 January 2025

Original Research

Clinical Outcomes of Hepatic Arterial Infusion Chemotherapy Plus Lenvatinib and Tislelizumab for Treating Hepatocellular Carcinoma and Type IV Portal Vein Tumor Thrombus

Li X, Cao K, Fu Z, Chen X, Zhong J, Liu L, Ding N, Zhang X, Qu Z, Zhu L, Zhai J

Journal of Hepatocellular Carcinoma 2025, 12:169-182

Published Date: 25 January 2025

Original Research

Design and Mechanism Study of 6c, a Novel Artesunate Derivatives, for Anti-Hepatocellular Carcinoma

Xiong SS

Journal of Hepatocellular Carcinoma 2025, 12:149-167

Published Date: 25 January 2025

Original Research

The Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors

Xin Y, Liu N, Peng G, Huang X, Cao X, Zhou X

Journal of Hepatocellular Carcinoma 2025, 12:135-147

Published Date: 24 January 2025

Original Research

Impact of Timing the Combination of Radiotherapy and PD-1 Inhibitors on Outcomes in Patients with Hepatocellular Carcinoma

Zhong L, Peng W, Sun J, Luo Y, Sheng H, Wu Y, Zhou T, Zhou C, Cao C

Journal of Hepatocellular Carcinoma 2025, 12:123-134

Published Date: 22 January 2025

Original Research

A New Risk Score Based on Lipid Indicators for Patients with Advanced Hepatocellular Carcinoma

Wei X, Guo Z, Zhang T, Liang J

Journal of Hepatocellular Carcinoma 2025, 12:107-121

Published Date: 21 January 2025

Original Research

Risk and Prognosis of Hepatocellular Carcinoma in Mexican Americans with Type 2 Diabetes Mellitus

Hatia RI, Hwang LY, Li R, Troisi C, Jalal PK, Amos CI, Gomez HF, Chun YS, Rashid A, Kaseb AO, Scheet PA, Hassan MM

Journal of Hepatocellular Carcinoma 2025, 12:93-106

Published Date: 21 January 2025

Original Research

A Machine Learning Model for Predicting Prognosis in HCC Patients With Diabetes After TACE

Wu L, Chen L, Zhang L, Liu Y, Ouyang D, Wu W, Lei Y, Han P, Zhao H, Zheng C

Journal of Hepatocellular Carcinoma 2025, 12:77-91

Published Date: 21 January 2025

Review

Progress in the Study of Intratumoral Microorganisms in Hepatocellular Carcinoma

Song Y, Tian S, Li Z, Miao J, Wu M, Xu T, Wu X, Qiao J, Zhang X, Zhao H, Kang L, Cao L, Zhu P, Miao M

Journal of Hepatocellular Carcinoma 2025, 12:59-76

Published Date: 18 January 2025

Original Research

Prediction of Pathologic Response in Unresectable Hepatocellular Carcinoma After Downstaging with Locoregional and Systemic Combination Therapy

Yang C, Chen Y, Sheng L, Wang Y, Zhang X, Yang Y, Ronot M, Jiang H, Song B

Journal of Hepatocellular Carcinoma 2025, 12:43-58

Published Date: 16 January 2025

Original Research

Fully Covered Stent-TIPS for Advanced HCC Patients with Portal Vein Tumor Thrombus-Related Severe Symptomatic Portal Hypertension

Liu Z, Lyu T, Yang J, Xie Y, Fan S, Song L, Zou Y, Wang J

Journal of Hepatocellular Carcinoma 2025, 12:29-41

Published Date: 14 January 2025

Original Research

Transarterial Chemoembolization Plus Radiofrequency Ablation and Iodine-125 Seed Implantation for Hepatocellular Carcinoma in High-Risk Locations: A Propensity Score-Matched Analysis

Zhang G, Ren Y, Liu J, Cao Y, Xiong F, Liang B, Zheng C, Kan X

Journal of Hepatocellular Carcinoma 2025, 12:15-27

Published Date: 10 January 2025

Original Research

Correlation Between Dynamic Contrast-Enhanced CT Imaging Signs and Differentiation Grade and Microvascular Invasion of Hepatocellular Carcinoma

Liu Y, Zhou Y, Liao C, Li H, Zhang X, Gong H, Pu H

Journal of Hepatocellular Carcinoma 2025, 12:1-14

Published Date: 8 January 2025